Ciona robusta (formerly C. intestinalis) as a model of gut host-microbe interactions
Liberti A, Zucchetti I, Melillo D, Skapura D, Shibata Y, De Santis R, Pinto MR, Litman GW, Dishaw LJ. Chitin protects the gut epithelial barrier in a protochordate model of DSS-induced colitis. Biol Open. 2018 Jan 17;7(1). pii: bio029355. doi: 10.1242/bio.029355. PubMed PMID: 29222175.
Below are some examples of the specific topics we are investigating:
Our work involves both in vivo and in vitro experiments and is supported by the NSF.
Some of our phage work involves a collaboration with Dr. Mya Breitbart.
We have developed and utilize Ciona germ-free mariculture approaches.
We are now investigating fungi as an important player in the maintenance of gut microbiome homeostasis.
Ciona juveniles are like mini- guts on plastic dishes... by the hundreds or thousands!