Ciona robusta (formerly C. intestinalis) as a model of gut host-microbe interactions
Liberti A, Zucchetti I, Melillo D, Skapura D, Shibata Y, De Santis R, Pinto MR, Litman GW, Dishaw LJ. Chitin protects the gut epithelial barrier in a protochordate model of DSS-induced colitis. Biol Open. 2018 Jan 17;7(1). pii: bio029355. doi: 10.1242/bio.029355. PubMed PMID: 29222175.
How do immune effectors influence the structure of the gut microbiome?
Our Research Focus
We work on VCBPs
Relationship between symbiosis and immunity
Host-microbe dialogue via innate receptors
The role(s) of adherent bacterial communities in the gut
Molecular phylogeny of immune response genes
Our research is supported by:
National Science Foundation (currently our phage studies)
National Institutes of Health (our collaboration with Dr. Groer in USF Nursing)
All Children’s Hospital Johns Hopkins Medicine Foundation (several studies)
University of South Florida College of Medicine Deans Office (several early studies in Ciona)