Ciona robusta (formerly C. intestinalis) as a model of gut host-microbe interactions
Creasy A, Rosario K, Leigh BA, Dishaw LJ, Breitbart M. Unprecedented Diversity of ssDNA Phages from the Family Microviridae Detected within the Gut of a Protochordate Model Organism (Ciona robusta). Viruses. 2018 Jul 31;10(8). pii: E404. doi: 10.3390/v10080404. PubMed PMID: 30065169; PubMed Central PMCID: PMC6116155.
Below are some examples of the specific topics we are investigating:
Our work involves both in vivo and in vitro experiments and is supported by the NSF.
Some of our phage work involves a collaboration with Dr. Mya Breitbart.
We have developed and utilize Ciona germ-free mariculture approaches.
We are now investigating fungi as an important player in the maintenance of gut microbiome homeostasis.
Ciona juveniles are like mini- guts on plastic dishes... by the hundreds or thousands!